Phenotypes Associated with This Genotype

Genotype
MGI:4359630

• Allelic Composition: Tg(Krt14-Angptl2)1Yo/0
• Genetic Background: C.Cg-Tg(Krt14-Angptl2)1Yo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

skin inflammation ( J:152387 , J:181261 )

• ears, snouts, and eyelids of mice are red (J:152387)

• the tail is reddish and swollen with loss of tips occurring from inflammation (J:152387)

• adherent leukocytes are apparent in skin blood vessels (J:152387)

• these blood vessels leak much more fluid than controls when administered an inflammatory agent (J:152387)

• skin associated lymphatics are enlarged (J:152387)

• accumulation of mucin in dermis, indicative of chronic inflammation (J:181261)

• infiltration of leukocytes in the skin tissue (J:181261)

• mutants exhibit a rash on the back skin (J:181261)

• eyelids of 30 month old mutants are red and swollen, a condition resembling heliotrope rash (J:181261)

limbs/digits/tail

abnormal tail tip morphology ( J:152387 )

• tips of tails are often lost due to inflammation

integument

skin inflammation ( J:152387 , J:181261 )

• ears, snouts, and eyelids of mice are red (J:152387)

• the tail is reddish and swollen with loss of tips occurring from inflammation (J:152387)

• adherent leukocytes are apparent in skin blood vessels (J:152387)

• these blood vessels leak much more fluid than controls when administered an inflammatory agent (J:152387)

• skin associated lymphatics are enlarged (J:152387)

• accumulation of mucin in dermis, indicative of chronic inflammation (J:181261)

• infiltration of leukocytes in the skin tissue (J:181261)

• mutants exhibit a rash on the back skin (J:181261)

• eyelids of 30 month old mutants are red and swollen, a condition resembling heliotrope rash (J:181261)

muscle

muscle phenotype ( J:181261 )

N • mutants do not exhibit abnormal muscle phenotypes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dermatomyositis		DOID:10223		J:181261