nervous system
• at P56 and P120 (about 55% and 25%), respectively, of nerves are abnormal with many promyelin configurations
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• at P16 nerves contain many promyelin configurations in contrast to wild type and heterozygotes in which >90% of large-caliber axons are myelinated
• at P56 and P120, abnormal axons are thinly myelinated resembling wild-type nerves during the first postnatal week
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