Phenotypes for Lmx1a Lmx1b Tg(Lmx1a-cre)1Kjmi MGI:4359810 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Lmx1a^dr-J/Lmx1a^dr-J Lmx1b^tm1Rjo/Lmx1b^tm1Zfc Tg(Lmx1a-cre)1Kjmi/0
Genetic Background	involves: 129S7/SvEvBrd * C3HeB/Fe * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmx1a^dr-J mutation (1 available); any Lmx1a mutation (21 available)
Lmx1b^tm1Rjo mutation (0 available); any Lmx1b mutation (16 available)
Lmx1b^tm1Zfc mutation (0 available); any Lmx1b mutation (16 available)
Tg(Lmx1a-cre)1Kjmi mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal fourth ventricle morphology ( J:152673 )

• fourth ventricle roof plate size is dramatically smaller relative to wild-type or Lmx1a-null mice at E10.5

abnormal cerebellum morphology ( J:152673 )

• P20 mice show severe cerebellar defects

abnormal cerebellum development ( J:152673 )

• at E12.5, reduced proliferation is observed in the cerebellar anlage

small cerebellum ( J:152673 )

• cerebellum is reduced in size

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24