Phenotypes Associated with This Genotype

Genotype
MGI:4359814

• Allelic Composition: Ttn^tm1Brge/Ttn⁺
• Genetic Background: B6.Cg-Ttn^tm1Brge

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:152736 )

N • under normal condition, mice exhibit normal cardiac function and mechanical properties

abnormal heart left ventricle morphology ( J:152736 )

• after 2 weeks of treatment with angiotensin II, mice exhibit increased left ventricular end-diastolic diameter (LVEDD) compared with similarly treated wild-type mice

• however, a normal decrease in LVEDD a week after angiotensin II treatment is observed

dilated heart left ventricle ( J:152736 )

• mice treated with angiotensin II or isoproterenol exhibit increased left ventricular dilation compared with similarly treated wild-type mice

cardiac interstitial fibrosis ( J:152736 )

• following treatment with angiotensin II or isoproterenol

dilated cardiomyopathy ( J:152736 )

• following treatment with angiotensin II or isoproterenol

decreased cardiac muscle contractility ( J:152736 )

• after 1 and 2 weeks of treatment with angiotensin II, mice exhibit decreased fractional shortening compared with similarly treated wild-type mice

• after treatment with isoproterenol, mice exhibit reduced ejection fraction and fractional shortening compared with similarly treated wild-type mice

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:152736 )

• mice treated with angiotensin II or isoproterenol exhibit left ventricular dilation, decreased fractional shortening, increased left ventricular end-diastolic diameter, and increased cardiac interstitial fibrosis compared with similarly treated wild-type mice

muscle

dilated cardiomyopathy ( J:152736 )

• following treatment with angiotensin II or isoproterenol

decreased cardiac muscle contractility ( J:152736 )

• after 1 and 2 weeks of treatment with angiotensin II, mice exhibit decreased fractional shortening compared with similarly treated wild-type mice

• after treatment with isoproterenol, mice exhibit reduced ejection fraction and fractional shortening compared with similarly treated wild-type mice

cellular

cardiac interstitial fibrosis ( J:152736 )

• following treatment with angiotensin II or isoproterenol

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy 1G		DOID:0110430	OMIM:604145	J:152736