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Phenotypes Associated with This Genotype
Genotype
MGI:4360302
Allelic
Composition
Tg(Myh6-CREB1*S133A)1Jml/0
Genetic
Background
involves: CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• between 2 and 20 weeks, mortality is greater than in wild-type mice
• over 40% of mice are dead by 20 weeks of age whereas all wild-type mice remain alive
• between 2 and 20 weeks, mortality is greater than in wild-type mice

cardiovascular system
• at 20 weeks, mice exhibit advanced chronic hepatic congestion unlike in wild-type mice
• mice exhibit liver with areas of central venous congestion unlike in wild-type mice
• mice exhibit heterogeneity in myocyte size with some vacuolization unlike in wild-type mice
• left ventricular end systolic and end diastolic dimensions are increased 33% and 18%, respectively, compared to in wild-type mice
• mice exhibit biventricular enlargement without an increase in wall thickness or increase in ventricular weight
• as early as 4 weeks, mice exhibit dilated cardiomyopathy in all four chambers of the heart unlike wild-type mice
• by 8 weeks, all mice exhibit dilated cardiomyopathy without inflammatory cell infiltration
• treatment with isoproterenol induces less of an increase in fractional shortening compared to in similarly treated wild-type mice
• left ventricular shortening fraction is decreased 35% compared to in wild-type mice
• treatment with isoproterenol exhibit reduced left ventricle diastolic and systolic pressure response compared with similarly treated wild-type mice
• 35% less than in wild-type mice
• 24% less than in wild-type mice
• some myocytes exhibit hypertrophy while others exhibit atrophy

homeostasis/metabolism
• atrial and ventricular
• between 8 and 20 weeks, mice exhibit severe peripheral edema unlike wild-type mice
• between 8 and 20 weeks
• treatment with isoproterenol induces less of an increase in fractional shortening compared to in similarly treated wild-type mice
• treatment with isoproterenol exhibit reduced left ventricle diastolic and systolic pressure response compared with similarly treated wild-type mice

liver/biliary system
• at 20 weeks, livers have a nutmeg appearance with dark red areas of central venous congestion and central lobular necrosis unlike in wild-type mice
• at 20 weeks, mice exhibit advanced chronic hepatic congestion unlike in wild-type mice
• mice exhibit liver with areas of central venous congestion unlike in wild-type mice
• at 20 weeks, mice exhibit central lobular necrosis unlike wild-type mice

respiratory system
• between 8 and 20 weeks

behavior/neurological
• between 8 and 20 weeks

muscle
• mice exhibit heterogeneity in myocyte size with some vacuolization unlike in wild-type mice
• as early as 4 weeks, mice exhibit dilated cardiomyopathy in all four chambers of the heart unlike wild-type mice
• by 8 weeks, all mice exhibit dilated cardiomyopathy without inflammatory cell infiltration
• treatment with isoproterenol induces less of an increase in fractional shortening compared to in similarly treated wild-type mice
• left ventricular shortening fraction is decreased 35% compared to in wild-type mice

growth/size/body

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
dilated cardiomyopathy DOID:12930 OMIM:PS115200
J:133881


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory