Phenotypes Associated with This Genotype

Genotype
MGI:4360685

• Allelic Composition: Apc^tm2Rfo/Apc⁺
• Genetic Background: (C57BL/6J x 129P2/OlaHsd)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Mammary adenocarcinomas from Apc^tm2Rfo/Apc⁺ mice

mortality/aging

premature death ( J:151494 )

• mice die prior to 21 weeks

neoplasm

increased metastatic potential ( J:204440 )

• lung micro- and macro-metastases

increased tumor incidence ( J:151494 )

♂ • mice develop epidermal cysts with increased multiplicity in male mice

♂ • however, mice do not exhibit an increased susceptibility to intestinal tumors

♂ • all tumors exhibit squamous metaplasia

increased mammary gland tumor incidence ( J:151494 )

• in 86% of virgin females and 31% of males

increased mammary adenocarcinoma incidence ( J:151494 , J:204440 )

• primary mammary adenocarcinomas metastasize to the lungs (J:151494)

• mice develop metaplastic mammary adenocarcinoma, a subtype of triple-negative breast cancer (J:204440)

increased liver tumor incidence ( J:151494 )

♂ • 31% of male mice develop liver tumors

♂ • however, female mice do not develop liver tumors

♂ • all tumors exhibit squamous metaplasia

increased desmoid tumor incidence ( J:151494 )

♂ • mice develop desmoids with increased multiplicity in male mice

integument

increased mammary gland tumor incidence ( J:151494 )

• in 86% of virgin females and 31% of males

increased mammary adenocarcinoma incidence ( J:151494 , J:204440 )

• primary mammary adenocarcinomas metastasize to the lungs (J:151494)

• mice develop metaplastic mammary adenocarcinoma, a subtype of triple-negative breast cancer (J:204440)

epidermal cyst ( J:151494 )

♂ • with increased mutliplicity in males

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:151494 )

• in 86% of virgin females and 31% of males

increased mammary adenocarcinoma incidence ( J:151494 , J:204440 )

• primary mammary adenocarcinomas metastasize to the lungs (J:151494)

• mice develop metaplastic mammary adenocarcinoma, a subtype of triple-negative breast cancer (J:204440)

growth/size/body

epidermal cyst ( J:151494 )

♂ • with increased mutliplicity in males

liver/biliary system

increased liver tumor incidence ( J:151494 )

♂ • 31% of male mice develop liver tumors

♂ • however, female mice do not develop liver tumors

♂ • all tumors exhibit squamous metaplasia

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:204440