Phenotypes Associated with This Genotype

Genotype
MGI:4360920

tg1

• Allelic Composition: Tg(GHRL-TAg)3-1Hiwa/0
• Genetic Background: C57BL/6-Tg(GHRL-TAg)3-1Hiwa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:152492 )

• at 15 weeks

decreased circulating insulin level ( J:152492 )

• after glucose injection

increased circulating insulin-like growth factor I level ( J:152492 )

• at 12 and 15 weeks

decreased circulating leptin level ( J:152492 )

• at 15 weeks

impaired glucose tolerance ( J:152492 )

neoplasm

increased stomach tumor incidence ( J:152492 )

• mice develop ghrelinoma

behavior/neurological

decreased food intake ( J:152492 )

• at 11 weeks, mice exhibit a decrease in food intake compared with wild-type mice

• however, injection with ghrelin increases food intake to levels observed in similarly treated wild-type mice

growth/size/body

decreased body weight ( J:152492 )

• at 13 weeks

adipose tissue

decreased total body fat amount ( J:152492 )

• at 15 weeks

digestive/alimentary system

gastric hypertrophy ( J:152492 )

• the stomach wall is hypertrophic

increased stomach tumor incidence ( J:152492 )

• mice develop ghrelinoma