Phenotypes Associated with This Genotype

Genotype
MGI:4361120

• Allelic Composition: Xpa^tm1Tnka/Xpa^tm1Tnka; Tg(KRT14-Kitl)1Takk/?
• Genetic Background: involves: C57BL/6 * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:100608 )

• black hair

abnormal epidermal pigmentation ( J:100608 )

• black skin

neoplasm

increased skin tumor incidence ( J:100608 )

• mice irradiated with UV-B 3X/week for 10 weeks, total dose 150J/cm²

• unevenly pigmented macules appear on re-epithelialized skin at 4 months after UV-B exposure

• lentigo maligna melanomas eventually become elevated tumors

• black nodular melanomas in some mice by 6 months after exposure

• at 53 weeks, 8 of 61 mice with nodular melanomas and 12 of 61 mice show lintigo maligna melanoma

• one type of tumor or the other, never both

increased metastatic potential ( J:100608 )

• melanoma cells invade the dermis

• both types of melanomas become metastatic

integument

abnormal coat/hair pigmentation ( J:100608 )

• black hair

abnormal epidermal pigmentation ( J:100608 )

• black skin

increased skin tumor incidence ( J:100608 )

• mice irradiated with UV-B 3X/week for 10 weeks, total dose 150J/cm²

• unevenly pigmented macules appear on re-epithelialized skin at 4 months after UV-B exposure

• lentigo maligna melanomas eventually become elevated tumors

• black nodular melanomas in some mice by 6 months after exposure

• at 53 weeks, 8 of 61 mice with nodular melanomas and 12 of 61 mice show lintigo maligna melanoma

• one type of tumor or the other, never both

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
skin melanoma		DOID:8923	OMIM:608035 OMIM:612263	J:100608