Phenotypes Associated with This Genotype

Genotype
MGI:4361196

• Allelic Composition: Tg(Krt19-Ptgs2,Krt19-Ptges)8Tko/0; Tg(Krt19-Wnt1)2Maos/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased tumor-free survival time ( J:116782 )

• some mice die between 25 and 50 weeks of age due to tumors

neoplasm

increased stomach tumor incidence ( J:116782 , J:153058 )

• 100% penetrance of dysplastic gastric tumors in mice older than 20 weeks of age, with tumors consisting of dysplastic epithelial cells with nuclear stratification and irregularly branched tubules (J:116782)

• tumors resemble human intestinal-type gastric cancer and gastric adenocarcinoma (J:116782)

• tumor invasion into the smooth muscle layers is seen in 50%, 75% and 100% of mutants at 20, 30, and 50 weeks of age, respectively (J:116782)

• tumors exhibit an accumulation of macrophages and increased angiogenesis (J:116782)

increased gastric adenocarcinoma incidence ( J:116782 )

digestive/alimentary system

abnormal stomach glandular epithelium morphology ( J:116782 )

• hyperproliferation of gastric epithelial cells

gastric metaplasia ( J:116782 )

• mutants exhibit mucous metaplasia as early as 5 weeks of age, before dysplastic tumor formation

increased stomach tumor incidence ( J:116782 , J:153058 )

• 100% penetrance of dysplastic gastric tumors in mice older than 20 weeks of age, with tumors consisting of dysplastic epithelial cells with nuclear stratification and irregularly branched tubules (J:116782)

• tumors resemble human intestinal-type gastric cancer and gastric adenocarcinoma (J:116782)

• tumor invasion into the smooth muscle layers is seen in 50%, 75% and 100% of mutants at 20, 30, and 50 weeks of age, respectively (J:116782)

• tumors exhibit an accumulation of macrophages and increased angiogenesis (J:116782)

increased gastric adenocarcinoma incidence ( J:116782 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
stomach cancer		DOID:10534	OMIM:613659	J:116782