Phenotypes Associated with This Genotype

Genotype
MGI:4361526

• Allelic Composition: Ifngr1^tm1Agt/Ifngr1^tm1Agt
• Genetic Background: B6.129S7-Ifngr1^tm1Agt/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:138728 )

• after induction of graft versus host disease

cellular

impaired osteoblast differentiation ( J:233116 )

• reduction of Runx2 expression in bone marrow cells indicating impaired osteoblast differentiation

• reduction of alkaline phosphatase-expressing cells (osteoblasts) indicating impaired late differentiation of osteoblasts

abnormal osteoclast differentiation ( J:233116 )

• reduction of RANKL expression in bone marrow cells, indicating impaired osteoclast differentiation

immune system

abnormal osteoclast differentiation ( J:233116 )

• reduction of RANKL expression in bone marrow cells, indicating impaired osteoclast differentiation

abnormal lymphopoiesis ( J:138728 )

• after induction of graft versus host disease, mice exhibit reduced numbers and proliferation of CD8+, CD4+, CD11b+, and CD19+ cells in the spleen compared with similarly treated wild-type cells

decreased lymphocyte cell number ( J:138728 )

• after induction of graft versus host disease, mice exhibit reduced numbers of CD8+, CD4+, CD11b+, and CD19+ cells in the spleen compared with similarly treated wild-type cells

decreased CD4-positive, alpha-beta T cell number ( J:138728 )

• after induction of graft versus host disease

decreased CD8-positive, alpha-beta T cell number ( J:138728 )

• after induction of graft versus host disease

spleen hypoplasia ( J:138728 )

• after induction of graft versus host disease

abnormal circulating chemokine level ( J:152785 )

• alphaGalCer-treated mice fail to exhibit an increase in circulating CXCL9 unlike similarly treated wild-type mice

decreased circulating interleukin-12 level ( J:152785 )

• 6 hours following treatment with alphaGalCer compared to in similarly treated wild-type mice

increased interferon-gamma secretion ( J:138728 )

• in the spleen and bone marrow after induction of graft versus host disease

decreased susceptibility to bacterial infection ( J:147443 )

• bacille Calmette-Guerin (BCG)-inoculated mice exhibit reduced depressive-like behavior in a forced swim and tail suspension tests and indoleamine 2,3-dioxygenase (IDO) activity compared with similarly treated wild-type mice

increased susceptibility to graft versus host disease ( J:138728 )

• after induction of graft versus host disease, mice exhibit early mortality, increased lung and skin pathology but decreased intestine pathology, increased IFN-gamma production in the spleen and bone marrow, increased spleen and bone marrow aplasia, decreased proliferation of hematopoietic stem/progenitor cells, and decreased lymphopoiesis compared with similarly treated wild-type mice

skeleton

impaired osteoblast differentiation ( J:233116 )

• reduction of Runx2 expression in bone marrow cells indicating impaired osteoblast differentiation

• reduction of alkaline phosphatase-expressing cells (osteoblasts) indicating impaired late differentiation of osteoblasts

abnormal osteoclast differentiation ( J:233116 )

• reduction of RANKL expression in bone marrow cells, indicating impaired osteoclast differentiation

decreased bone volume ( J:233116 )

• 45% reduction in bone volume

decreased compact bone thickness ( J:233116 )

decreased osteoblast cell number ( J:233116 )

decreased osteocyte number ( J:233116 )

• mean number of osteocytes per cortical bone at the metaphyseal level is lower

decreased bone trabecula number ( J:233116 )

decreased trabecular bone thickness ( J:233116 )

osteoporosis ( J:233116 )

decreased bone mineralization ( J:233116 )

• reduction of mineralized surfaces of bone of 4 week old mice

• reduction in mineral-apposition rate in 4 week old mice

• reduction of osteopontin expression within the trabeculae and in cortical bone indicating impaired mineralization

decreased bone ossification ( J:233116 )

• reduction in bone-formation rate in 4 week old mice

decreased bone resorption ( J:233116 )

• markers of bone resorption (RANKL and N-telopeptide) are reduced

neoplasm

increased metastatic potential ( J:152785 )

• following treatment with alphaGalCer, mice fail to exhibit a reduction in the number of B16F10 tumors metastasizing to the lungs unlike similarly treated wild-type mice

• mice exhibit increased metastasis of B16F10 tumors to the lungs compared with wild-type mice

homeostasis/metabolism

decreased circulating osteocalcin level ( J:233116 )

• lower circulating concentrations of the bone-formation marker osteocalcin

abnormal circulating chemokine level ( J:152785 )

• alphaGalCer-treated mice fail to exhibit an increase in circulating CXCL9 unlike similarly treated wild-type mice

decreased circulating interleukin-12 level ( J:152785 )

• 6 hours following treatment with alphaGalCer compared to in similarly treated wild-type mice

hematopoietic system

abnormal osteoclast differentiation ( J:233116 )

• reduction of RANKL expression in bone marrow cells, indicating impaired osteoclast differentiation

abnormal lymphopoiesis ( J:138728 )

• after induction of graft versus host disease, mice exhibit reduced numbers and proliferation of CD8+, CD4+, CD11b+, and CD19+ cells in the spleen compared with similarly treated wild-type cells

decreased bone marrow cell number ( J:138728 )

• after induction of graft versus host disease

decreased lymphocyte cell number ( J:138728 )

• after induction of graft versus host disease, mice exhibit reduced numbers of CD8+, CD4+, CD11b+, and CD19+ cells in the spleen compared with similarly treated wild-type cells

decreased CD4-positive, alpha-beta T cell number ( J:138728 )

• after induction of graft versus host disease

decreased CD8-positive, alpha-beta T cell number ( J:138728 )

• after induction of graft versus host disease

spleen hypoplasia ( J:138728 )

• after induction of graft versus host disease

abnormal hematopoietic system physiology ( J:138728 )

• after induction of graft versus host disease, proliferation of hematopoietic stem/progenitor cells compared to in similarly treated wild-type mice

behavior/neurological

abnormal depression-related behavior ( J:147443 )

• bacille Calmette-Guerin (BCG)-inoculated mice exhibit reduced depressive-like behavior in a forced swim and tail suspension tests compared with similarly treated wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
osteoporosis		DOID:11476	OMIM:166710	J:233116