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Phenotypes Associated with This Genotype
Genotype
MGI:4361564
cx4
Allelic
Composition		 Map3k14aly/Map3k14+
RelbTg(H2-K1/GH1)106Bri/Relb+
Genetic
Background		 involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k14aly mutation (3 available); any Map3k14 mutation (41 available)
RelbTg(H2-K1/GH1)106Bri mutation (1 available); any Relb mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK T cell number ( J:120659 )
• Valpha14i NKT cells are reduced in the thymus, spleen, liver, and bone marrow compared to in wild-type mice and RelbTg(H2-K1/GH1)106Bri heterozygotes
decreased circulating interferon-gamma level ( J:120659 )
• alpha-GalCer-treated mice exhibit a reduction in IFN-gamma serum levels compared to in single heterozygotes
decreased Peyer's patch number ( J:120659 )
• greater than in RelbTg(H2-K1/GH1)106Bri heterozygotes
small Peyer's patches ( J:120659 )
• greater than in RelbTg(H2-K1/GH1)106Bri heterozygotes

homeostasis/metabolism
decreased circulating interferon-gamma level ( J:120659 )
• alpha-GalCer-treated mice exhibit a reduction in IFN-gamma serum levels compared to in single heterozygotes

hematopoietic system
decreased NK T cell number ( J:120659 )
• Valpha14i NKT cells are reduced in the thymus, spleen, liver, and bone marrow compared to in wild-type mice and RelbTg(H2-K1/GH1)106Bri heterozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory