Phenotypes Associated with This Genotype

Genotype
MGI:4361565

hm2

• Allelic Composition: Relb^{Tg(H2-K1/GH1)106Bri}/Relb^{Tg(H2-K1/GH1)106Bri}
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased NK T cell number ( J:120659 )

• Valpha14i NKT cells are reduced in the thymus, spleen, liver, and bone marrow compared to in wild-type mice

decreased circulating interleukin-4 level ( J:120659 )

• serum from alpha-GalCer-treated mice lacks IL4 unlike similarly treated wild-type mice

absent Peyer's patches ( J:120659 )

absent lymph nodes ( J:120659 )

increased inflammatory response ( J:120659 )

• mice develop multi-organ inflammation unlike wild-type mice

homeostasis/metabolism

decreased circulating interleukin-4 level ( J:120659 )

• serum from alpha-GalCer-treated mice lacks IL4 unlike similarly treated wild-type mice

hematopoietic system

decreased NK T cell number ( J:120659 )

• Valpha14i NKT cells are reduced in the thymus, spleen, liver, and bone marrow compared to in wild-type mice