Phenotypes for Dmd Spp1 MGI:4361735 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Dmd^mdx/Dmd^mdx Spp1^tm1Blh/Spp1^tm1Blh
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * C57BL/10ScSn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmd^mdx mutation (31 available); any Dmd mutation (156 available)
Spp1^tm1Blh mutation (2 available); any Spp1 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Reduced diaphragm and cardiac fibrosis in Dmd^mdx/Y Spp1^tm1Blh/Spp1^tm1Blh and Dmd^mdx/Dmd^mdx Spp1^tm1Blh/Spp1^tm1Blh mice compared to Dmd^mdx/Dmd^mdx mice

immune system

decreased granulocyte number ( J:150572 )

• muscles contain fewer granulocytes than in Dmd^mdx homozygotes

decreased neutrophil cell number ( J:150572 )

• muscles contain fewer neutrophils than in Dmd^mdx homozygotes

decreased T cell number ( J:150572 )

• muscles contain fewer CD3+/Vbeta8.1/8.2+, and NKT-like cells than in Dmd^mdx homozygotes

increased T cell number ( J:150572 )

• muscles contain more CD3+ T cells than in Dmd^mdx homozygotes

increased regulatory T cell number ( J:150572 )

• muscles contain more CD3+CD4+ regulatory T cells than in Dmd^mdx homozygotes

muscle

abnormal muscle physiology ( J:150572 )

• mice exhibit improved muscle regeneration and reduced muscle inflammation and fibrosis in the diaphragm and heart compared with Dmd^mdx homozygotes

behavior/neurological

abnormal physical strength ( J:150572 )

• at 4 and 8 weeks, mice exhibit increased strength on a wire and grip test compared with Dmd^mdx homozygotes

hematopoietic system

decreased granulocyte number ( J:150572 )

• muscles contain fewer granulocytes than in Dmd^mdx homozygotes

decreased neutrophil cell number ( J:150572 )

• muscles contain fewer neutrophils than in Dmd^mdx homozygotes

decreased T cell number ( J:150572 )

• muscles contain fewer CD3+/Vbeta8.1/8.2+, and NKT-like cells than in Dmd^mdx homozygotes

increased T cell number ( J:150572 )

• muscles contain more CD3+ T cells than in Dmd^mdx homozygotes

increased regulatory T cell number ( J:150572 )

• muscles contain more CD3+CD4+ regulatory T cells than in Dmd^mdx homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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