Phenotypes Associated with This Genotype

Genotype
MGI:4361902

cx6

• Allelic Composition: Alpl^tm1Jlm/Alpl^tm1Jlm; Spp1^tm1Rit/Spp1^tm1Rit
• Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal osteoblast physiology ( J:128077 )

• calvarial osteoblasts form larger mineralized nodules compared with Alpl^tm1Jlm homozygous cells

mortality/aging

postnatal lethality, complete penetrance ( J:128077 )

• mice die within 10 to 14 days of birth

skeleton

abnormal osteoblast physiology ( J:128077 )

• calvarial osteoblasts form larger mineralized nodules compared with Alpl^tm1Jlm homozygous cells

increased bone mineral density of presacral vertebrae ( J:128077 )

• bone marrow density and bone volume fraction in thoracic vertebrae are increased compared to in Alpl^tm1Jlm homozygotes

increased bone mineral density of lumbar vertebrae ( J:128077 )

• bone marrow density and bone volume fraction in lumbar vertebrae are increased compared to in wild-type mice

• bone volume fraction in lumbar vertebrae are increased compared to in wild-type mice and Spp1^tm1Rit homozygotes

increased bone trabecula number ( J:128077 )

• trabecular number is greater than in Alpl^tm1Jlm homozygotes and wild-type mice

decreased bone mineralization ( J:128077 )

• mineral deposition is decreased compared to in wild-type mice

growth/size/body

decreased body weight ( J:128077 )