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Phenotypes Associated with This Genotype
Genotype
MGI:4361903
hm3
Allelic
Composition		 Alpltm1Jlm/Alpltm1Jlm
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alpltm1Jlm mutation (0 available); any Alpl mutation (352 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal osteoblast physiology ( J:128077 )
• calvarial osteoblasts from smaller mineralized nodules compared with Alpltm1Jlm homozygous cells
decreased bone mineral density ( J:128077 )
• phosphate and calcium deposition in bone is decreased compared to in wild-type mice

cellular
abnormal osteoblast physiology ( J:128077 )
• calvarial osteoblasts from smaller mineralized nodules compared with Alpltm1Jlm homozygous cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory