Phenotypes Associated with This Genotype

Genotype
MGI:4361924

• Allelic Composition: Tg(MMTV-PyVT)634Mul/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:133325 , J:236031 )

• average onset of tumor development is 66 days (J:133325)

• tumor nodules are present throughout the entire mammary gland (J:133325)

• extensive adenomas are found (J:133325)

• primary tumors are highly fibrotic (J:236031)

• tumors exhibit more linear, thicker collagen fibers consistent with aggressive and invasive tumors (J:236031)

• tumors have higher CD31 staining, indicating increased primary tumor vasculature (J:236031)

endocrine/exocrine glands

abnormal mammary gland morphology ( J:133325 )

♀ • tumor nodules are present throughout the entire mammary gland

increased mammary gland tumor incidence ( J:133325 , J:236031 )

• average onset of tumor development is 66 days (J:133325)

• tumor nodules are present throughout the entire mammary gland (J:133325)

• extensive adenomas are found (J:133325)

• primary tumors are highly fibrotic (J:236031)

• tumors exhibit more linear, thicker collagen fibers consistent with aggressive and invasive tumors (J:236031)

• tumors have higher CD31 staining, indicating increased primary tumor vasculature (J:236031)

integument

abnormal mammary gland morphology ( J:133325 )

♀ • tumor nodules are present throughout the entire mammary gland

increased mammary gland tumor incidence ( J:133325 , J:236031 )

• average onset of tumor development is 66 days (J:133325)

• tumor nodules are present throughout the entire mammary gland (J:133325)

• extensive adenomas are found (J:133325)

• primary tumors are highly fibrotic (J:236031)

• tumors exhibit more linear, thicker collagen fibers consistent with aggressive and invasive tumors (J:236031)

• tumors have higher CD31 staining, indicating increased primary tumor vasculature (J:236031)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:236031