Phenotypes Associated with This Genotype

Genotype
MGI:4365606

cx21

• Allelic Composition: Apc^Min/Apc⁺; Il6^tm1Kopf/Il6^tm1Kopf
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

muscle phenotype ( J:130429 )

N • no gastrocnemius muscle wasting

adipose tissue

adipose tissue phenotype ( J:130429 )

N • normal epididymal fat pads

neoplasm

abnormal tumor incidence ( J:130429 )

• numbers of gastrointestinal polyps 32% lower at 26 weeks than when both Il6 alleles are wild-type

• polyp sizes are reduced