Phenotypes Associated with This Genotype

Genotype
MGI:4365946

• Allelic Composition: Ts(17¹⁶)65Dn/0
• Genetic Background: B6EiC3Sn.BLiA-Ts(17¹⁶)65Dn/DnJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:153579 )

decreased body length ( J:153579 )

• the length from the nost to the tip of the tail is shorter than in background controls, although the length from the nose to the base of the tail does not have a statistically significant difference

behavior/neurological

abnormal learning/memory/conditioning ( J:153579 )

• in 22 degree water there is increased latency of acquisition of the hidden platform in the Morris water maze test

impaired contextual conditioning behavior ( J:153579 )

impaired cued conditioning behavior ( J:153579 )

abnormal spatial learning ( J:153579 )

decreased grip strength ( J:153579 )

• output of a grip strength meter shows reduced grip force relative to controls

hyperactivity ( J:153579 )

• although activity during the light cycle is not different from that of controls, during the dark cycle the total activity is significantly greater than in background controls

increased vertical activity ( J:153579 )

• significantly increased dark cycle rearing

increased stereotypic behavior ( J:153579 )

• significantly increased dark cycle horizontal and vertical stereotypic activity

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Down syndrome		DOID:14250	OMIM:190685	J:153579