Phenotypes Associated with This Genotype

Genotype
MGI:4366153

• Allelic Composition: Tg(SFTPC-env)1Yhch/0
• Genetic Background: FVB/N-Tg(SFTPC-env)1Yhch

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased metastatic potential ( J:247986 )

• tumor metastasis is seen at late stages, with metastatic nodules at chest wall and inguinal region

increased lung tumor incidence ( J:153538 )

• from 1 month onward mice develop lung tumors that increase in size with age unlike wild-type mice

• by 6 to 7 months 56% of mice develop tumors

• tumors are composed of type II pneumocytes

increased lung adenocarcinoma incidence ( J:153538 , J:247986 )

• lung tumors progress from atypical adenomatous hyperplasia, to adenocarcinoma in situ (bronchioloalveolar carcinoma) and after 6 months of age to adenocarcinoma featuring glandular/acinar architecture and desmoplasia (J:247986)

respiratory system

increased lung tumor incidence ( J:153538 )

• from 1 month onward mice develop lung tumors that increase in size with age unlike wild-type mice

• by 6 to 7 months 56% of mice develop tumors

• tumors are composed of type II pneumocytes

increased lung adenocarcinoma incidence ( J:153538 , J:247986 )

• lung tumors progress from atypical adenomatous hyperplasia, to adenocarcinoma in situ (bronchioloalveolar carcinoma) and after 6 months of age to adenocarcinoma featuring glandular/acinar architecture and desmoplasia (J:247986)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung adenocarcinoma		DOID:3910		J:247986
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:153538