Phenotypes Associated with This Genotype

Genotype
MGI:4366162

• Allelic Composition: Ttc7^fsn/Ttc7^fsn
• Genetic Background: involves: A/J * BALB/cByJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal hair shaft morphology ( J:29609 )

• SEM shows pits, striations, and exophytic protrusions typify hair shaft appearance

abnormal hair cuticle ( J:29609 )

• all hair types exhibit irregularities in the cuticular scales

abnormal nail morphology ( J:29609 )

• nails are bent at a 90 degree angle, have surface irregularities with accumulation of scale at the nail base

deformed nails ( J:29609 )

abnormal epidermal layer morphology ( J:29609 )

• layer is abnormally thick and TEM images show an infiltration of neutrophils

increased dendritic epidermal T cell number ( J:14506 )

• numbers of Thy-1+ dendritic epidermal cells are elevated at all ages in the epidermal sheets from the ear and overall increased, though varied at different ages, in the epidermal sheets from the foot pad

• numbers of Asialo-GM1+ cells are increased in the dorsal skin at all ages, with major increases between 2 and 4 weeks of age

abnormal keratohyalin granule morphology ( J:29609 )

hypergranulosis ( J:29609 )

• Background Sensitivity: can be modulated by genetic background; not typical of an A/J background

abnormal keratinocyte morphology ( J:29609 )

• TEM images show mitochondrial abnormalities

thick epidermis ( J:14506 , J:29609 )

• epidermis increases in thickness through 4 weeks of age and remains thick over 8 weeks (J:14506)

hematopoietic system

increased dendritic epidermal T cell number ( J:14506 )

• numbers of Thy-1+ dendritic epidermal cells are elevated at all ages in the epidermal sheets from the ear and overall increased, though varied at different ages, in the epidermal sheets from the foot pad

• numbers of Asialo-GM1+ cells are increased in the dorsal skin at all ages, with major increases between 2 and 4 weeks of age

increased Langerhans cell number ( J:14506 )

• numbers of Langerhans cells are increased at all ages in epidermal sheets from ears, increased after 4 weeks of age in the epidermal sheets from foot pads, and elevated after 3 weeks in the dorsal skin

immune system

increased dendritic epidermal T cell number ( J:14506 )

• numbers of Thy-1+ dendritic epidermal cells are elevated at all ages in the epidermal sheets from the ear and overall increased, though varied at different ages, in the epidermal sheets from the foot pad

• numbers of Asialo-GM1+ cells are increased in the dorsal skin at all ages, with major increases between 2 and 4 weeks of age

increased Langerhans cell number ( J:14506 )

• numbers of Langerhans cells are increased at all ages in epidermal sheets from ears, increased after 4 weeks of age in the epidermal sheets from foot pads, and elevated after 3 weeks in the dorsal skin

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
psoriasis		DOID:8893	OMIM:PS177900	J:14506