Phenotypes Associated with This Genotype

Genotype
MGI:4366531

• Allelic Composition: Tg(Camk2a-App*,-Apbb1)25Spim/0
• Genetic Background: C57BL/6-Tg(Camk2a-App*,-Apbb1)25Spim

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased susceptibility to neuronal excitotoxicity ( J:153738 )

• at 4 months, mice treated with kainic acid exhibit neuron loss similar to in aged Tg(Camk2a-App*,-Apbb1)25Spim mice but unlike similarly treated wild-type mice

tau protein deposits ( J:153738 )

• mice exhibit age-dependent somatodendritic aggregations of phosphorylated tau protein unlike in wild-type mice

neurodegeneration ( J:153738 )

• age-dependent neuron loss is observed in mice older than 18 months in the CA3 region and to a lesser extent in the dentate gyrus unlike in wild-type mice

• at 4 months, mice treated with kainic acid exhibit neuron loss similar to in aged Tg(Camk2a-App*,-Apbb1)25Spim mice but unlike similarly treated wild-type mice

behavior/neurological

behavior/neurological phenotype ( J:153738 )

N • mice exhibit normal excitability and exploratory behavior

abnormal spatial working memory ( J:153738 )

• at 8 months, mice exhibit a decrease in spontaneous alteration in a Y-maze unlike wild-type mice

• however, young mice and mice treated with lithium exhibit normal working memory

homeostasis/metabolism

increased susceptibility to neuronal excitotoxicity ( J:153738 )

• at 4 months, mice treated with kainic acid exhibit neuron loss similar to in aged Tg(Camk2a-App*,-Apbb1)25Spim mice but unlike similarly treated wild-type mice

cellular

increased susceptibility to neuronal excitotoxicity ( J:153738 )

• at 4 months, mice treated with kainic acid exhibit neuron loss similar to in aged Tg(Camk2a-App*,-Apbb1)25Spim mice but unlike similarly treated wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:153738