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Phenotypes Associated with This Genotype
Genotype
MGI:4366764
cn3
Allelic
Composition
Ets2tm1Rgo/Ets2tm5.1Rgo
Ptentm1.1Mwst/Ptentm1.1Mwst
Tg(S100a4-cre)1Gle/0
Genetic
Background
involves: 129S2/SvPas * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm1Rgo mutation (1 available); any Ets2 mutation (39 available)
Ets2tm5.1Rgo mutation (0 available); any Ets2 mutation (39 available)
Ptentm1.1Mwst mutation (0 available); any Pten mutation (89 available)
Tg(S100a4-cre)1Gle mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• fewer and smaller tumors form in mice injected with the mammary tumor line NT2.5 compared to in similarly treated Ptentm1.1Mwst/Ptentm1.1Mwst Tg(S100a4-cre)1Gle mice
• mice injected with the mammary tumor line NT2.5 develop more mammary tumors than in similarly treated Ptentm1.1Mwst homozygotes
• mammary tumors induced by NT2.5 exhibit decreased numbers of macrophages and recruitment of new vasculature compared to in similarly treated Ptentm1.1Mwst homozygotes

integument
• fewer and smaller tumors form in mice injected with the mammary tumor line NT2.5 compared to in similarly treated Ptentm1.1Mwst/Ptentm1.1Mwst Tg(S100a4-cre)1Gle mice
• mice injected with the mammary tumor line NT2.5 develop more mammary tumors than in similarly treated Ptentm1.1Mwst homozygotes

endocrine/exocrine glands
• fewer and smaller tumors form in mice injected with the mammary tumor line NT2.5 compared to in similarly treated Ptentm1.1Mwst/Ptentm1.1Mwst Tg(S100a4-cre)1Gle mice
• mice injected with the mammary tumor line NT2.5 develop more mammary tumors than in similarly treated Ptentm1.1Mwst homozygotes


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory