Phenotypes for Dmd Nos1 MGI:4366781 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Dmd^mdx/Y Nos1^tm1Plh/Nos1^tm1Plh
Genetic Background	involves: 129S4/SvJae * C57BL/10ScSn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmd^mdx mutation (31 available); any Dmd mutation (156 available)
Nos1^tm1Plh mutation (3 available); any Nos1 mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

dystrophic muscle ( J:48851 )

• mice show severe dystrophic changes in the muscle

homeostasis/metabolism

abnormal circulating pyruvate kinase level ( J:48851 )

• marked elevation of pyruvate kinase levels is detectable by P21, absence of Nos1 expression does not significantly change pyruvate kinase levels compared to mice hemizygous for Dmd^mdx and heterozygous for Nos1^tm1Plh

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24