Phenotypes for Dmd Nos1 MGI:4366782 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Dmd^mdx/Dmd⁺ Nos1^tm1Plh/Nos1^tm1Plh
Genetic Background	involves: 129S4/SvJae * C57BL/10ScSn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmd^mdx mutation (33 available); any Dmd mutation (167 available)
Nos1^tm1Plh mutation (3 available); any Nos1 mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

dystrophic muscle ( J:48851 )

• mice show isolated dystrophic changes in the muscle

homeostasis/metabolism

abnormal circulating pyruvate kinase level ( J:48851 )

• moderate elevation of pyruvate kinase levels is detectable by P21, absence of Nos1 expression does not significantly change pyruvate kinase levels compared to mice heterozygous for both Dmd^mdx and Nos1^tm1Plh

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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