Phenotypes Associated with This Genotype

Genotype
MGI:4367101

• Allelic Composition: Apobec1^tm1Ddsn/Apobec1^tm1Ddsn; Ldlr^tm1Her/Ldlr^tm1Her
• Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating cholesterol level ( J:49125 )

• total cholesterol levels are higher in males than females

• on a high fat diet total cholesterol reaches 1600 mg/dl by 8 weeks

increased circulating LDL cholesterol level ( J:49125 )

• elevated in both sexes but higher in males than females

increased circulating triglyceride level ( J:49125 )

• modestly elevated

cardiovascular system

atherosclerotic lesions ( J:49125 )

• extensive lesions along the length of the aorta at 8 months

• lesions are somewhat more extensive in males but otherwise the sexes are similar

• on a high fat diet lesions cover 9% of the aorta surface by 8 weeks

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial hypercholesterolemia		DOID:13810	OMIM:143890	J:49125