Phenotypes Associated with This Genotype

Genotype
MGI:4367205

• Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her; Tg(APPSWE)2576Kha/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal response to new environment ( J:114480 )

• fail to show intersession habituation over 3 days of testing in an open field, unlike transgenic mice wild-type for Ldlr

abnormal spatial learning ( J:114480 )

• learning impairment in a Morris water maze at 10 months of age

• impairment not affected by Ldlr genotype

abnormal long-term spatial reference memory ( J:114480 )

• at 13 months of age mice trained at 10 months of age are slower to reacquire the location of the hidden platform in a morris water maze compared to transgenic mice wild-type for Ldlr

• in a probe trial mice fail to occupy the target quadrant longer than chance indicating memory retention deficits

decreased anxiety-related response ( J:114480 )

• make more entries into the open arms of an elevated plus maze on day 2 of testing

hyperactivity ( J:114480 )

• relative to non-transgenic controls

homeostasis/metabolism

amyloidosis ( J:114480 )

• age dependent cerebral amyloidosis

• plaques first appear in the hippocampus and cortex at around 11 months

• progressive accumulation in the brain after 11 months

amyloid beta deposits ( J:114480 )

• cerebral amyloid beta deposition is increased compared to transgenic mice wild-type for Ldlr

increased circulating cholesterol level ( J:114480 )

• hypercholesterolemia with the increase in the non-HDL fraction

increased circulating LDL cholesterol level ( J:114480 )

• increase is mainly in the LDL fraction

nervous system

amyloid beta deposits ( J:114480 )

• cerebral amyloid beta deposition is increased compared to transgenic mice wild-type for Ldlr

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:114480