Phenotypes Associated with This Genotype

Genotype
MGI:4367270

• Allelic Composition: Rho^R3/Rho^tm1Jlem
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

retina outer nuclear layer degeneration ( J:153281 )

• between 14 and 21 days of age, complex heterozygotes for these two alleles exhibit progressive loss of ONL nuclei of intermediate severity between that of Rho^R3/+ and Rho^R3 homozygous mice

• from 21 days, by which the homozygous ENU mutants entirely lack ONL nuclei, the compound heterozygotes retain approximately half as many as Rho^R3/+ mice until both level out at day 35, Rho^R3/+ mice with 2 rows of nuclei and the compound heterozygotes with a single row

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
retinitis pigmentosa 4		DOID:0110372	OMIM:613731	J:153281