Phenotypes Associated with This Genotype

Genotype
MGI:4367450

• Allelic Composition: Ank1^pale/Ank1^pale
• Genetic Background: C57BL/6J-Ank1^pale/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

The pale and lethal phenotype of Ank1^pale/Ank1^pale mice

mortality/aging

postnatal lethality, complete penetrance ( J:154215 )

• homozygotes usually die within within the first week of life, although some have survived to 3 or 4 weeks of age

prenatal lethality, incomplete penetrance ( J:154215 )

• heterozygous intercrosses yield fewer than 25% homozygotes

growth/size/body

decreased body size ( J:154215 )

pigmentation

abnormal skin pigmentation ( J:154215 )

• homozygotes have a pale light grey skin color evident at birth

integument

abnormal skin pigmentation ( J:154215 )

• homozygotes have a pale light grey skin color evident at birth

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hereditary spherocytosis type 1		DOID:0110916	OMIM:182900	J:222308