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Phenotypes Associated with This Genotype
Genotype
MGI:4367704
cx14
Allelic
Composition		 Mmp9tm1Tvu/Mmp9tm1Tvu
Tg(SOD1*G93A)1Gur/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp9tm1Tvu mutation (2 available); any Mmp9 mutation (50 available)
Tg(SOD1*G93A)1Gur mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:141587 )
N
• mice survive 31% longer than Tg(SOD1*G93A)1Gur mice

nervous system
nervous system phenotype ( J:141587 )
N
• neuron loss observed in Tg(SOD1*G93A)1Gur mice is attenuated

immune system
decreased tumor necrosis factor secretion ( J:141587 )
• TNF-alpha staining is absent from neuronal cells in the spinal cord unlike in Tg(SOD1*G93A)1Gur mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory