Phenotypes for Dmd Mmp9 MGI:4367736 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Dmd^mdx/Dmd^mdx Mmp9^tm1Tvu/Mmp9⁺
Genetic Background	B10.Cg-Mmp9^tm1Tvu Dmd^mdx

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmd^mdx mutation (31 available); any Dmd mutation (156 available)
Mmp9^tm1Tvu mutation (2 available); any Mmp9 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal muscle morphology ( J:150030 )

• mice exhibit improved muscle and sarcolemmal structure, more uniform fiber diameter, reduced inflammatory cell between adjacent fibers, and decreased necrosis and fibrosis compared with Dmd^mdx homozygotes

abnormal muscle physiology ( J:150030 )

• mice exhibit higher muscle force production compared with Dmd^mdx homozygotes

enhanced skeletal muscle regeneration ( J:150030 )

• myofiber regeneration is increased compared to in Dmd^mdx homozygotes

immune system

decreased macrophage cell number ( J:150030 )

• fewer macrophages accumulate in the muscles compared to in Dmd^mdx homozygotes

hematopoietic system

decreased macrophage cell number ( J:150030 )

• fewer macrophages accumulate in the muscles compared to in Dmd^mdx homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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