Phenotypes Associated with This Genotype

Genotype
MGI:4397671

• Allelic Composition: Kcnq2^tm1.1Naas/Kcnq2^tm1.1Naas
• Genetic Background: B6.129-Kcnq2^tm1.1Naas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:154582 )

• some mice die between P23 and P32

neonatal lethality, incomplete penetrance ( J:154582 )

• some mice die at P0

nervous system

tonic-clonic seizures ( J:154582 )

• between P24 and P52, mice exhibit at least one tonic-clonic seizure of the fore- or hindlimbs unlike wild-type mice

growth/size/body

decreased body size ( J:154582 )

• at weaning, mice are 22% to 46% smaller than wild-type mice

behavior/neurological

tonic-clonic seizures ( J:154582 )

• between P24 and P52, mice exhibit at least one tonic-clonic seizure of the fore- or hindlimbs unlike wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
benign neonatal seizures		DOID:14264	OMIM:121200 OMIM:121201 OMIM:269720	J:154582