Analysis Tools
mortality/aging
|
• after P15, mice exhibit increased mortality compared with wild-type mice
• 20% of mice die during or after a spontaneous seizure
|
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• some mice die at P0
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nervous system
| N |
• despite seizures, mice exhibit no hippocampal mossy fiber sprouting or neuronal loss
|
|
• mice exhibit spontaneous seizures as early as the second postnatal week unlike wild-type mice
• after weaning, mice exhibit multiple spontaneous recurrent seizures unlike wild-type mice
• at P30 to P45, mice exhibit a decline in seizure severity
• by P65 to P75, mice exhibit low grade seizures with bilateral forelimb clonus, orofacial automatisms, jaw chomping, head clonus, occasional falling, and rearing
• clusters of seizures increase with age while severity decreases
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|
• after recurrent seizures, mice exhibit selected regions of necrosis in the hippocampus unlike in wild-type mice
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astrocytosis
(
J:154582
)
|
• in multiple hippocampal regions at P32 and P120
|
growth/size/body
behavior/neurological
|
• mice exhibit spontaneous seizures as early as the second postnatal week unlike wild-type mice
• after weaning, mice exhibit multiple spontaneous recurrent seizures unlike wild-type mice
• at P30 to P45, mice exhibit a decline in seizure severity
• by P65 to P75, mice exhibit low grade seizures with bilateral forelimb clonus, orofacial automatisms, jaw chomping, head clonus, occasional falling, and rearing
• clusters of seizures increase with age while severity decreases
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| benign neonatal seizures | DOID:14264 |
OMIM:121200 OMIM:121201 OMIM:269720 |
J:154582 | |
