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Phenotypes Associated with This Genotype
Genotype
MGI:4398718
Allelic
Composition
Tg(Pcp2-SCA7)P7EJman/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mutants show impaired performance on the rotarod at 11 months of age, but not earlier, and are unable to improve their performance during successive days

nervous system
• at 16 months of age, but not at 11 months, mutants exhibit a reduction in the density of Purkinje cells, indicating degeneration
• at 16 months of age, but not at 11 months, mutants exhibit a reduction in the dendritic arbor of Purkinje cells
• progressive formation of ubiquitin and proteasome-immunoreactive nuclear inclusions composed of the N-terminal fragment of the mutant protein

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
spinocerebellar ataxia type 7 DOID:0050958 OMIM:164500
J:65411


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory