Phenotypes Associated with This Genotype

Genotype
MGI:4398737

• Allelic Composition: Smn1^tm1Msd/Smn1^tm1Rako
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:154248 )

• most mice die by 1 month of age

nervous system

decreased motor neuron number ( J:154248 )

• in the brain stem and spinal cord at P21

skeleton

abnormal spine curvature ( J:154248 )

• in mice that survive beyond 1 month

behavior/neurological

abnormal gait ( J:154248 )

• in mice that survive beyond 1 month

paraparesis ( J:154248 )

• mice that survive beyond 1 month exhibit hind limb weakness

growth/size/body

decreased body size ( J:154248 )

• at 3 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Werdnig-Hoffmann disease		DOID:13137	OMIM:253300	J:154248