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Phenotypes Associated with This Genotype
Genotype
MGI:4398737
Allelic
Composition
Smn1tm1Msd/Smn1tm1Rako
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smn1tm1Msd mutation (37 available); any Smn1 mutation (87 available)
Smn1tm1Rako mutation (0 available); any Smn1 mutation (87 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mice die by 1 month of age

nervous system
• in the brain stem and spinal cord at P21

skeleton
• in mice that survive beyond 1 month

behavior/neurological
• in mice that survive beyond 1 month
• mice that survive beyond 1 month exhibit hind limb weakness

growth/size/body
• at 3 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Werdnig-Hoffmann disease DOID:13137 OMIM:253300
J:154248


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory