Phenotypes Associated with This Genotype

Genotype
MGI:4399117

hm2

• Allelic Composition: Timp3^tm1Osya/Timp3^tm1Osya
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:154709 )

N • mice exhibit normal passive avoidance and active avoidance

abnormal learning/memory/conditioning ( J:154709 )

• after several days in an open-field, mice fail to become accustomed to their environment, as determined by maintenance of novel environment locomotion and rearing levels, unlike similarly treated wild-type mice

abnormal spatial learning ( J:154709 )

• in a water maze test with invisible platform, mice exhibit reduced memory acquisition on day 2 compared with wild-type mice

• deficit in memory acquisition in a water maze test with invisible platform lessens with time

• however, by day 5 memory acquisition in a water maze with invisible platform is normal and performance in a water maze test with visible platform is normal

cardiovascular system

cardiovascular system phenotype ( J:211441 )

N • whether or not infused with angiotensin II, mice exhibit normal heart rate

abnormal artery morphology ( J:211441 )

• disorganized extracellular matrix collagen fibers with reduced collagen I protein level in the carotid arteries of mice treated with angiotensin II

• however, doxycycline treatment prevents aberrant arterial extracellular matrix degradation

abnormal blood vessel elastic tissue morphology ( J:211441 )

• disorganized and interrupted elastin fibers and lower elastin protein content in carotid arteries of mice treated with angiotensin II

abnormal systemic arterial blood pressure ( J:211441 )

• following angiotensin II infusion, mice fail to exhibit an increase in blood pressure as observed in wild-type mice

decreased systemic arterial blood pressure ( J:211441 )

• at baseline

abnormal blood vessel physiology ( J:211441 )

• following angiotensin II infusion, mesenteric arteries exhibit a reduced increase in media to lumen ratio with reduced medial thickness and increased lumen diameter compared with wild-type mice

• however, doxycycline treatment prevents reduction in media to lumen ratio

decreased vasodilation ( J:211441 )

• following angiotensin II infusion, arteries are more distensible than in wild-type mice

• however, doxycycline treatment prevents reduction lumen dilation

muscle

decreased vasodilation ( J:211441 )

• following angiotensin II infusion, arteries are more distensible than in wild-type mice

• however, doxycycline treatment prevents reduction lumen dilation