Analysis Tools
mortality/aging
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• fewer than expected mice survive
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• some mice die by E14.5
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cardiovascular system
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• in 54% of mice at E10.5
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• in 46% of mice at E10.5 (23% left and 38% right)
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• 8% of mice exhibit defects in the left sixth branchial arch artery unlike wild-type mice
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• 2% of mice exhibit defects in the right pulmonary trunk defect
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• at E14.5, 4% of mice exhibit type B interrupted aortic arches unlike wild-type mice
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• at E14.5, 2% of mice exhibit cervical arch or B-segment coarcation unlike wild-type mice
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• at E14.5, 16% of mice exhibit aberrant right subclavian artery unlike wild-type mice
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• 28% of mice exhibit abnormal great vessels unlike wild-type mice
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nervous system
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• the vagus nerve is reduced compared to in wild-type mice
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• in some mice
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embryo
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• in 54% of mice at E10.5
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• in 46% of mice at E10.5 (23% left and 38% right)
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• 8% of mice exhibit defects in the left sixth branchial arch artery unlike wild-type mice
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• mice exhibit subtly altered neural crest cell migration to the caudal pharyngeal region compared with wild-type mice
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craniofacial
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• in 54% of mice at E10.5
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• in 46% of mice at E10.5 (23% left and 38% right)
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• 8% of mice exhibit defects in the left sixth branchial arch artery unlike wild-type mice
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behavior/neurological
cellular
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• mice exhibit subtly altered neural crest cell migration to the caudal pharyngeal region compared with wild-type mice
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