cardiovascular system
• at E10.5, 6 of 17 mice exhibit bilateral fourth pharyngeal arch aplasia compared with 1 of 9 single heterozygotes
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• at E14.5, mice exhibit an increase in interrupted aortic arches compared with either single heterozygote
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• at E14.5, 7 of 17 mice exhibit aberrant right subclavian artery unlike wild-type mice
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craniofacial
• at E10.5, 6 of 17 mice exhibit bilateral fourth pharyngeal arch aplasia compared with 1 of 9 single heterozygotes
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embryo
• at E10.5, 6 of 17 mice exhibit bilateral fourth pharyngeal arch aplasia compared with 1 of 9 single heterozygotes
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hearing/vestibular/ear
hematopoietic system
• at E14.5, 4 of 17 mice exhibit ectopic thymus gland unlike single heterozygotes
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immune system
• at E14.5, 4 of 17 mice exhibit ectopic thymus gland unlike single heterozygotes
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endocrine/exocrine glands
• at E14.5, 4 of 17 mice exhibit ectopic thymus gland unlike single heterozygotes
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