About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4410364
cx10
Allelic
Composition
Chd7Gt(XK403)Byg/Chd7+
Tbx1tm1Bld/Tbx1+
Genetic
Background
either: (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6) or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chd7Gt(XK403)Byg mutation (0 available); any Chd7 mutation (138 available)
Tbx1tm1Bld mutation (1 available); any Tbx1 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Pharyngeal arch artery patterning defects in Chd7Whi/Chd7+, Chd7Gt(XK403)Byg/Chd7+ and Chd7Gt(XK403)Byg/Chd7+ Tbx1tm1Bld/Tbx1+ embryos

cardiovascular system
• at E10.5, 6 of 17 mice exhibit bilateral fourth pharyngeal arch aplasia compared with 1 of 9 single heterozygotes
• at E14.5, mice exhibit an increase in interrupted aortic arches compared with either single heterozygote
• at E14.5, 7 of 17 mice exhibit aberrant right subclavian artery unlike wild-type mice

craniofacial
• at E10.5, 6 of 17 mice exhibit bilateral fourth pharyngeal arch aplasia compared with 1 of 9 single heterozygotes

embryo
• at E10.5, 6 of 17 mice exhibit bilateral fourth pharyngeal arch aplasia compared with 1 of 9 single heterozygotes

hearing/vestibular/ear

hematopoietic system
• at E14.5, 4 of 17 mice exhibit ectopic thymus gland unlike single heterozygotes

immune system
• at E14.5, 4 of 17 mice exhibit ectopic thymus gland unlike single heterozygotes

endocrine/exocrine glands
• at E14.5, 4 of 17 mice exhibit ectopic thymus gland unlike single heterozygotes


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/10/2024
MGI 6.24
The Jackson Laboratory

Building initial tooltip...