Phenotypes Associated with This Genotype

Genotype
MGI:4410378

cn3

• Allelic Composition: Tbx1^tm1Bld/Tbx1^tm2.1Bem; Tfap2a^tm1(cre)Moon/Tfap2a⁺
• Genetic Background: either: (involves: 129/Sv * C57BL/6 * SJL) or (involves: 129/Sv * C57BL/6J * CBA * SJL)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal aortic arch morphology ( J:154590 )

• in 9 of 20 mice

aberrant origin of the right subclavian artery ( J:154590 )

• at E15.5, 11 of 20 mice exhibit aberrant right subclavian artery unlike wild-type mice

abnormal cardiac outflow tract development ( J:154590 )

• mice exhibit defects in the great vessels unlike wild-type mice

persistent truncus arteriosus ( J:154590 )

• one mouse exhibits truncus arteriosus communis unlike wild-type mice

ventricular septal defect ( J:154590 )

• at E15.5 in one mouse

• at E18.5 in one mouse

craniofacial

cleft palate ( J:154590 )

• in 9 of 20 mice

immune system

thymus hypoplasia ( J:154590 )

• 12 of 20 mice exhibit an absent or hypoplastic thymus unlike wild-type mice

athymia ( J:154590 )

• 12 of 20 mice exhibit an absent or hypoplastic thymus unlike wild-type mice

digestive/alimentary system

cleft palate ( J:154590 )

• in 9 of 20 mice

hematopoietic system

thymus hypoplasia ( J:154590 )

• 12 of 20 mice exhibit an absent or hypoplastic thymus unlike wild-type mice

athymia ( J:154590 )

• 12 of 20 mice exhibit an absent or hypoplastic thymus unlike wild-type mice

endocrine/exocrine glands

thymus hypoplasia ( J:154590 )

• 12 of 20 mice exhibit an absent or hypoplastic thymus unlike wild-type mice

athymia ( J:154590 )

• 12 of 20 mice exhibit an absent or hypoplastic thymus unlike wild-type mice

growth/size/body

cleft palate ( J:154590 )

• in 9 of 20 mice