About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4412016
Allelic
Composition
Hbbd3th/Hbb+
Tg(HBB-AR-HBA2,-HBB*)58Rub/0
Tg(LCR-HBA2,LCR-HBB)11Cos/0
Genetic
Background
involves: FVB/N * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbbd3th mutation (4 available); any Hbb mutation (47 available)
Tg(HBB-AR-HBA2,-HBB*)58Rub mutation (1 available)
Tg(LCR-HBA2,LCR-HBB)11Cos mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• after 7 hours of water deprivation, mice exhibit a reduced capacity to concentrate urine compared with similarly treated wild-type mice

renal/urinary system
• after 7 hours of water deprivation, mice exhibit a reduced capacity to concentrate urine compared with similarly treated wild-type mice

hematopoietic system
• mice exhibit neonatal anemia
• under deoxygenated conditions, more than 17% of cells sickle in less than 50 seconds unlike wild-type cells

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
sickle cell anemia DOID:10923 J:94190


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
07/02/2024
MGI 6.13
The Jackson Laboratory