Phenotypes Associated with This Genotype

Genotype
MGI:4412021

• Allelic Composition: Apc^tm1Rak/Apc⁺; Mlh1^tm1Rak/Mlh1^tm1Rak
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:53451 )

• all mice die by 4 months of age

neoplasm

increased tumor incidence ( J:53451 )

• all mice develop tumors at an average age of 3.3 months

• all mice develop gastrointestinal tract tumors and 9% develop non-gastrointestinal tract tumors

increased gastrointestinal tumor incidence ( J:53451 )

• all mice develop gastrointestinal tract tumors

• mice exhibit a 30-fold increase in gastrointestinal tumors compared to Mlh1^tm1Rak homozygotes

• mice exhibit a 4- to 5-fold increase in stomach and colon tumors, and a 25- to 100-fold increase in duodenum, jejunum, and ileum compared to in homozygous mice

increased skin tumor incidence ( J:53451 )

• one mouse develops skin carcinoma with lung metastasis

increased adenoma incidence ( J:53451 )

• 34% of mice develop microadenomas and 36% adenomas

increased lymphoma incidence ( J:53451 )

• non-Hodgkin's lymphoma in two mice

increased carcinoma incidence ( J:53451 )

• mice develop gastrointestinal adenocarcinomas, early invasive carcinomas (in 13% of mice), and carcinomas (in 17% of mice)

increased adenocarcinoma incidence ( J:53451 )

digestive/alimentary system

melena ( J:53451 )

• at 2 to 4 weeks of age

increased gastrointestinal tumor incidence ( J:53451 )

• all mice develop gastrointestinal tract tumors

• mice exhibit a 30-fold increase in gastrointestinal tumors compared to Mlh1^tm1Rak homozygotes

• mice exhibit a 4- to 5-fold increase in stomach and colon tumors, and a 25- to 100-fold increase in duodenum, jejunum, and ileum compared to in homozygous mice

integument

increased skin tumor incidence ( J:53451 )

• one mouse develops skin carcinoma with lung metastasis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Lynch syndrome		DOID:3883	OMIM:PS120435	J:53451