Phenotypes Associated with This Genotype

Genotype
MGI:4412047

• Allelic Composition: Nfkb2^Lym1/Nfkb2⁺
• Genetic Background: BALB/c-Nfkb2^Lym1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased lymphocyte cell number ( J:154812 )

• increased number of circulating lymphocytes

abnormal spleen white pulp morphology ( J:154812 )

• abnormalities in splenic architecture in heterozygous mice are intermediate between that of wild-type and homozygous null mice

immune system

increased lymphocyte cell number ( J:154812 )

• increased number of circulating lymphocytes

abnormal spleen white pulp morphology ( J:154812 )

• abnormalities in splenic architecture in heterozygous mice are intermediate between that of wild-type and homozygous null mice

absent Peyer's patches ( J:154812 )

abnormal lymph node morphology ( J:154812 )

abnormal mesenteric lymph node morphology ( J:154812 )

• mesenteric lymph nodes are present, but are reduced in size and cellularity

decreased lymph node number ( J:154812 )

absent axillary lymph nodes ( J:154812 )

absent brachial lymph nodes ( J:154812 )

absent cervical lymph nodes ( J:154812 )

absent inguinal lymph nodes ( J:154812 )

liver inflammation ( J:154812 )

• small foci composed of T and B cells, and macrophages are present in the liver of heterozygous mice

lung inflammation ( J:154812 )

• small foci composed of T and B cells, and macrophages are present in the lung of heterozygous mice

liver/biliary system

liver inflammation ( J:154812 )

• small foci composed of T and B cells, and macrophages are present in the liver of heterozygous mice

respiratory system

lung inflammation ( J:154812 )

• small foci composed of T and B cells, and macrophages are present in the lung of heterozygous mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
common variable immunodeficiency		DOID:12177	OMIM:PS607594	J:206674