Analysis Tools
mortality/aging
immune system
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• osteoclasts formation in response to RANKL stimulation is reduced
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• proliferation in response to CD40L, LPS, or BCR ligation is significantly reduced
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• double positive, double negative, and CD4 single positive cells are significantly increased in number while the number of CD8 positive cells is unchanged
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• thymus is enlarged in young homozygous null mice compared with wild-type
• with age the thymus becomes smaller in size and cellularity compared with age-matched wild-type
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• an increased proportion of the CD4 single positive cells had the appearance of recent thymic emigrants (CD69-, CD62L+), suggesting that thymic export may be impaired
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• does not correlate with an increase in splenocyte number
• enlargement becomes more pronounced with age
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• isotype switching in vitro in response to CD40L, LPS, or BCR ligation is reduced
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• number of transitional stage 2 B cells is profoundly reduced
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• number of transitional stage 1 B cells is significantly increased
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• plasma cell differentiation in vitro in response to CD40L, LPS, or BCR ligation is reduced
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• a slight reduction in expression of CD44 suggests that T cells are more naive
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• mature recirculating B cells are significantly reduced in the bone marrow
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• profoundly reduced
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• in the thymus and blood
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• in the blood
• but not in the thymus
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• absence of the ring of marginal metallophillic macrophages that normally surrounds the marginal zone
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• profoundly reduced
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• the number of follicular dendritic cell clusters is severely reduced
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• B cells are not segregated into discrete compartments
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• T cells are not segregated into discrete compartments
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• expression analysis indicates that inflammation in the lung and liver is due to an autoimmune process
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• large foci composed of T and B cells, and macrophages are present in the liver of homozygous null mice
• progressive increase in inflammation with age
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• large foci composed of T and B cells, and macrophages are present in the lung of homozygous null mice
• progressive increase in inflammation with age
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reproductive system
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• reduced fertility with less frequent litters and smaller litter sizes
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liver/biliary system
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• large foci composed of T and B cells, and macrophages are present in the liver of homozygous null mice
• progressive increase in inflammation with age
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respiratory system
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• large foci composed of T and B cells, and macrophages are present in the lung of homozygous null mice
• progressive increase in inflammation with age
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skeleton
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• osteoclasts formation in response to RANKL stimulation is reduced
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• significantly increased trabecular bone volume and number, but no change in trabecular thickness
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• mild
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hematopoietic system
| N |
• the proportion and number of pro-B, pre-B, and immature B cells in the bone marrow are unchanged, suggesting that early B cell development is normal
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• osteoclasts formation in response to RANKL stimulation is reduced
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• proliferation in response to CD40L, LPS, or BCR ligation is significantly reduced
|
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• double positive, double negative, and CD4 single positive cells are significantly increased in number while the number of CD8 positive cells is unchanged
|
|
• thymus is enlarged in young homozygous null mice compared with wild-type
• with age the thymus becomes smaller in size and cellularity compared with age-matched wild-type
|
|
• an increased proportion of the CD4 single positive cells had the appearance of recent thymic emigrants (CD69-, CD62L+), suggesting that thymic export may be impaired
|
|
• does not correlate with an increase in splenocyte number
• enlargement becomes more pronounced with age
|
|
• isotype switching in vitro in response to CD40L, LPS, or BCR ligation is reduced
|
|
• number of transitional stage 2 B cells is profoundly reduced
|
|
• number of transitional stage 1 B cells is significantly increased
|
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• plasma cell differentiation in vitro in response to CD40L, LPS, or BCR ligation is reduced
|
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• a slight reduction in expression of CD44 suggests that T cells are more naive
|
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• increase in erythropoiesis in the spleen
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• mature recirculating B cells are significantly reduced in the bone marrow
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• profoundly reduced
|
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• in the thymus and blood
|
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• in the blood
• but not in the thymus
|
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• absence of the ring of marginal metallophillic macrophages that normally surrounds the marginal zone
|
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• profoundly reduced
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• the number of follicular dendritic cell clusters is severely reduced
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• B cells are not segregated into discrete compartments
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• T cells are not segregated into discrete compartments
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cellular
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• osteoclasts formation in response to RANKL stimulation is reduced
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• proliferation in response to CD40L, LPS, or BCR ligation is significantly reduced
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endocrine/exocrine glands
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• double positive, double negative, and CD4 single positive cells are significantly increased in number while the number of CD8 positive cells is unchanged
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• thymus is enlarged in young homozygous null mice compared with wild-type
• with age the thymus becomes smaller in size and cellularity compared with age-matched wild-type
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• an increased proportion of the CD4 single positive cells had the appearance of recent thymic emigrants (CD69-, CD62L+), suggesting that thymic export may be impaired
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growth/size/body
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• does not correlate with an increase in splenocyte number
• enlargement becomes more pronounced with age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| common variable immunodeficiency | DOID:12177 |
OMIM:PS607594 |
J:206674 | |
