nervous system
• from 4 to 16 months, mice exhibit amyloid beta deposits unlike wild-type mice
• amyloid beta deposits worsen with age
|
• at 4 months, mice exhibit tau plaques unlike wild-type mice
• tau deposits worsen with age
|
behavior/neurological
• in a Morris water maze, mice exhibit increased swim speed during cued acquisition at 2 and 4 months compared with wild-type mice
• in a Morris water maze, mice exhibit exhibited decreased spatial learning at 4 and 12 months compared with wild-type mice
|
• in a novel arena at 2 and 12 months but not at 4 months
|
homeostasis/metabolism
• from 4 to 16 months, mice exhibit amyloid beta deposits unlike wild-type mice
• amyloid beta deposits worsen with age
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
Alzheimer's disease | DOID:10652 | J:154968 | ||
cerebral amyloid angiopathy | DOID:9246 | J:154968 |