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Phenotypes Associated with This Genotype
Genotype
MGI:4412051
Allelic
Composition
Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz/0
Tg(Thy1-MAPT)183Gotz/0
Genetic
Background
B6.Cg-Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz Tg(Thy1-MAPT)183Gotz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz mutation (1 available)
Tg(Thy1-MAPT)183Gotz mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• from 4 to 16 months, mice exhibit amyloid beta deposits unlike wild-type mice
• amyloid beta deposits worsen with age
• at 4 months, mice exhibit tau plaques unlike wild-type mice
• tau deposits worsen with age

behavior/neurological
• in a Morris water maze, mice exhibit increased swim speed during cued acquisition at 2 and 4 months compared with wild-type mice
• in a Morris water maze, mice exhibit exhibited decreased spatial learning at 4 and 12 months compared with wild-type mice
• in a novel arena at 2 and 12 months but not at 4 months

homeostasis/metabolism
• from 4 to 16 months, mice exhibit amyloid beta deposits unlike wild-type mice
• amyloid beta deposits worsen with age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 J:154968
cerebral amyloid angiopathy DOID:9246 J:154968


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory