Phenotypes Associated with This Genotype

Genotype
MGI:4415156

cn1

• Allelic Composition: Cdx2^tm1.1Lhn/Cdx2^tm1.1Lhn; Tg(CAG-cre/ERT2)F34Fmr/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:154904 )

• when mice are exposed to tamoxifen beginning at E5.5, mice die around E11.5

• however, mice exposed to tamoxifen beginning at E8.5 survive to term

embryo

abnormal mesoderm development ( J:154904 )

• when mice are exposed to tamoxifen beginning at E5.5, mice lack presomitic and posterior mesoderm

short rostral-caudal axis ( J:154904 )

• when mice are exposed to tamoxifen beginning at E5.5, mice exhibit a shortened anterior posterior axis by E8.5 compared with Cdx2^tm1.1Lhn homozygotes

• when mice are exposed to tamoxifen beginning at E8.5, mice exhibit axial truncation at the level of the sacral vertebrae at E18.5

abnormal presomitic mesoderm morphology ( J:154904 )

• when mice are exposed to tamoxifen beginning at E5.5, mice lack presomitic mesoderm

absent hindlimb buds ( J:154904 )

• when mice are exposed to tamoxifen beginning at E5.5, mice fail to develop hind limb buds

decreased somite size ( J:154904 )

• when mice are exposed to tamoxifen beginning at E5.5, somites after the first 5 through 7 are progressively smaller than in Cdx2^tm1.1Lhn homozygotes

impaired somite development ( J:154904 )

• when mice are exposed to tamoxifen beginning at E5.5, mice have fewer, more posteriorly located somites at E9.5 and E10.5 compared with Cdx2^tm1.1Lhn homozygotes

limbs/digits/tail

absent hindlimb buds ( J:154904 )

• when mice are exposed to tamoxifen beginning at E5.5, mice fail to develop hind limb buds