Phenotypes Associated with This Genotype

Genotype
MGI:4417896

• Allelic Composition: Tg(Krt14-Fyn)AJsey/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:118155 )

• 10% of the mice having the diffuse epidermal scale die by 1 week of age

growth/size/body

abnormal filiform papillae morphology ( J:118155 )

• loss of the filiform papillae in the runted mice

• hyperkeratosis of the dorsal tongue in the runted mice

decreased body size ( J:118155 )

• 10% of the mice having the diffuse epidermal scale are runted

behavior/neurological

decreased eating frequency ( J:118155 )

• decreased feeding activity in 10% of the mice having the diffuse epidermal scale

digestive/alimentary system

abnormal filiform papillae morphology ( J:118155 )

• loss of the filiform papillae in the runted mice

• hyperkeratosis of the dorsal tongue in the runted mice

craniofacial

abnormal filiform papillae morphology ( J:118155 )

• loss of the filiform papillae in the runted mice

• hyperkeratosis of the dorsal tongue in the runted mice

integument

abnormal keratinocyte morphology ( J:118155 )

• keratinocytes are larger and exhibit nuclear atypia

• hyperproliferation as shown by Ki-67 staining and BrdUrd labeling of keratinocytes

epidermal hyperplasia ( J:118155 )

• over a period of few weeks, diffuse scaling coalesces into prominent hyperkeratotic plaques lacking hair

• plaques usually resolve by 8 weeks

• no spontaneous epidermal tumors are seen in unstimulated mice (n=25) carried to 6 months

thick epidermis ( J:118155 )

psoriasis ( J:118155 )

• diffuse epidermal scale at 2-3 days post-natal, prominent by 7 days

• mixed inflammatory infiltrate containing lymphocytes and neutrophils present in the superficial dermis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
skin disease		DOID:37		J:118155