Phenotypes Associated with This Genotype

Genotype
MGI:4417919

• Allelic Composition: Slc1a1^tm1Wst/Slc1a1^tm1Wst
• Genetic Background: B6.129-Slc1a1^tm1Wst

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:124191 )

N • despite retinal ganglion cell loss and glaucomatous-like changes, mice exhibit normal intraocular pressure

decreased retina ganglion cell number ( J:124191 )

• after 8 weeks, mice exhibit loss of retinal ganglion cells (RGCs) associated with oxidative stress unlike wild-type mice

optic nerve degeneration ( J:124191 )

homeostasis/metabolism

increased lactate dehydrogenase level ( J:124191 )

• in retinal ganglion cells treated with hydrogen peroxide

cellular

increased cellular sensitivity to hydrogen peroxide ( J:124191 )

• retinal ganglion cells exhibit increased susceptibility to hydrogen peroxide compared with similarly treated wild-type cells

nervous system

decreased retina ganglion cell number ( J:124191 )

• after 8 weeks, mice exhibit loss of retinal ganglion cells (RGCs) associated with oxidative stress unlike wild-type mice

optic nerve degeneration ( J:124191 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
low tension glaucoma		DOID:13544		J:124191