Phenotypes for Cdkn2a Ctnnb1 Pten Tg(Tyr-cre/ERT2)13Bos MGI:4418449 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Ctnnb1^tm1Mmt/Ctnnb1^tm1Mmt Pten^tm1Rps/Pten^tm1Rps Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background	involves: 129/Sv * C57BL/6J * FVB * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm1Rdp mutation (6 available); any Cdkn2a mutation (67 available)
Ctnnb1^tm1Mmt mutation (0 available); any Ctnnb1 mutation (49 available)
Pten^tm1Rps mutation (1 available); any Pten mutation (88 available)
Tg(Tyr-cre/ERT2)13Bos mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased melanoma incidence ( J:155731 )

• following 4-hydroxytamoxifen (4-OHT) application, all mice develop melanoma over a 9 month period unlike wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
melanoma		DOID:1909		J:155731

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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