Phenotypes Associated with This Genotype

Genotype
MGI:4418482

cx49

• Allelic Composition: Cav1^tm1Mls/Cav1^tm1Mls; Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp
• Genetic Background: involves: 129/Sv * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell cycle ( J:90334 )

• MEFs exhibit an increase in the S-phase fraction and a decrease in the G0/G1 fraction, indicating an arrest in the G0/G1 phase

increased fibroblast proliferation ( J:90334 )

• MEFs exhibit increased hyperproliferation compared to single Cdkn2a homozygous MEFs

endocrine/exocrine glands

abnormal mammary gland duct morphology ( J:90334 )

♀ • fibrosis of the mammary gland epithelial duct

♀ • increase in ductal wall thickness

abnormal branching of the mammary ductal tree ( J:90334 )

♀ • increase in side-branching of the mammary gland epithelial duct

mammary gland duct hyperplasia ( J:90334 )

♀ • hyperplasia of the mammary gland epithelial duct

integument

abnormal mammary gland duct morphology ( J:90334 )

♀ • fibrosis of the mammary gland epithelial duct

♀ • increase in ductal wall thickness

abnormal branching of the mammary ductal tree ( J:90334 )

♀ • increase in side-branching of the mammary gland epithelial duct

mammary gland duct hyperplasia ( J:90334 )

♀ • hyperplasia of the mammary gland epithelial duct