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Phenotypes Associated with This Genotype
Genotype
MGI:4418525
cn6
Allelic
Composition		 Hif1atm3Rsjo/Hif1atm3Rsjo
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Hprt1tm1(Pck1-cre)Vhh/Y
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (1027 available)
Hif1atm3Rsjo mutation (3 available); any Hif1a mutation (50 available)
Hprt1tm1(Pck1-cre)Vhh mutation (0 available); any Hprt1 mutation (1281 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
kidney inflammation ( J:130751 )
• after ureteral ligation, mice exhibit reduced fibrosis and inflammation compared with similarly treated Hif1atm3Rsjo/Hif1atm3Rsjo Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ mice
renal fibrosis ( J:130751 )
• after ureteral ligation, mice exhibit reduced fibrosis and inflammation compared with similarly treated Hif1atm3Rsjo/Hif1atm3Rsjo Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ mice

cellular
abnormal cell differentiation ( J:130751 )
• hypoxic primary tubular epithelial cells fails to undergo an epithelial to mesenchyme transition unlike similarly treated cells from Hif1atm3Rsjo/Hif1atm3Rsjo Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ mice

homeostasis/metabolism
decreased susceptibility to injury ( J:130751 )
• after ureteral ligation, mice exhibit reduced fibrosis and inflammation compared with similarly treated Hif1atm3Rsjo/Hif1atm3Rsjo Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ mice

immune system
kidney inflammation ( J:130751 )
• after ureteral ligation, mice exhibit reduced fibrosis and inflammation compared with similarly treated Hif1atm3Rsjo/Hif1atm3Rsjo Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory