Phenotypes Associated with This Genotype

Genotype
MGI:4420228

• Allelic Composition: Scn4a^tm1.1Ljh/Scn4a^tm1.1Ljh
• Genetic Background: B6.129S4-Scn4a^tm1.1Ljh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:135831 )

perinatal lethality, incomplete penetrance ( J:135831 )

• phenotype is stated to be identical to that of Scn4a^tm1Ljh homozygotes, however, no data is presented in J:135831

muscle

abnormal skeletal muscle fiber morphology ( J:135831 )

increased variability of skeletal muscle fiber size ( J:135831 )

skeletal muscle atrophy ( J:135831 )

muscle weakness ( J:135831 )

myopathy ( J:135831 )

behavior/neurological

limb grasping ( J:135831 )

growth/size/body

decreased body weight ( J:135831 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hyperkalemic periodic paralysis		DOID:14451	OMIM:170500	J:135831